Publications

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Prof Anzala Aggrey O. Publications
12016Early Antibody Lineage Diversification And Independent Limb Maturation Lead To Broad HIV-1 Neutralization Targeting The Env High-Mannose Patch.
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22016Prevalence And Risk Factors Of Three Curable Sexually Transmitted Infections Among Women In Nairobi, Kenya.
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32016Periodic Presumptive Treatment For Vaginal Infections May Reduce The Incidence Of Sexually Transmitted Bacterial Infections.
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42016Assessment Of The Safety And Immunogenicity Of 2 Novel Vaccine Platforms For HIV-1 Prevention: A Randomized Trial.
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52016Broadly Neutralizing Antibody Responses In A Large Longitudinal Sub-Saharan HIV Primary Infection Cohort.
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62015A Phase I Double Blind, Placebo-Controlled, Randomized Study Of The Safety And Immunogenicity Of Electroporated HIV DNA With Or Without Interleukin 12 In Prime-Boost Combinations With An Ad35 HIV Vaccine In Healthy HIV-Seronegative African Adults.
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72015CD4:CD8 Lymphocyte Ratio As A Quantitative Measure Of Immunologic Health In HIV-1 Infection: Findings From An African Cohort With Prospective Data.
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82015Canine Distemper Virus Neutralization Activity Is Low In Human Serum And It Is Sensitive To An Amino Acid Substitution In The Hemagglutinin Protein.
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92015Creating An African HIV Clinical Research And Prevention Trials Network: HIV Prevalence, Incidence And Transmission.
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102015Randomized Trial Of Periodic Presumptive Treatment With High-Dose Intravaginal Metronidazole And Miconazole To Prevent Vaginal Infections In HIV-negative Women.
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112015Understanding Adherence To Daily And Intermittent Regimens Of Oral HIV Pre-exposure Prophylaxis Among Men Who Have Sex With Men In Kenya.
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122015Early HIV-1 Infection Is Associated With Reduced Frequencies Of Cervical Th17 Cells.
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132014Acceptability And Feasibility Of Repeated Mucosal Specimen Collection In Clinical Trial Participants In Kenya.
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142014Host Genetics And Viral Load In Primary HIV-1 Infection: Clear Evidence For Gene By Sex Interactions.
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152014Dynamics Of Viremia In Primary HIV-1 Infection In Africans: Insights From Analyses Of Host And Viral Correlates.
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162014Development Of A Luciferase Based Viral Inhibition Assay To Evaluate Vaccine Induced CD8 T-cell Responses.
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172014HIV Type 1 Transmission Networks Among Men Having Sex With Men And Heterosexuals In Kenya.
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182013HLA-B*57 Versus HLA-B*81 In HIV-1 Infection: Slow And Steady Wins The Race?
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192013Disease Progression By Infecting HIV-1 Subtype In A Seroconverter Cohort In Sub-Saharan Africa.
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202012HIV-1 Clade D Is Associated With Increased Rates Of CD4 Decline In A Kenyan Cohort
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212012Blunted IL17/IL22 And Pro-inflammatory Cytokine Responses In The Genital Tract And Blood Of HIV-exposed, Seronegative Female Sex Workers In Kenya.
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222012Safety And Adherence To Intermittent Pre-exposure Prophylaxis (PrEP) For HIV-1 In African Men Who Have Sex With Men And Female Sex Workers.
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232012Developing Standards Of Care For HIV Prevention Research In Developing Countries -- A Case Study Of 10 Research Centers In Eastern And Southern Africa.
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242012Differences In HIV Natural History Among African And Non-African Seroconverters In Europe And Seroconverters In Sub-Saharan Africa.
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252012Identifying At-risk Populations In Kenya And South Africa: HIV Incidence In Cohorts Of Men Who Report Sex With Men, Sex Workers, And Youth.
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262012What Impact Would An HIV/AIDS Vaccine Have On The HIV/AIDS Epidemic In Kenya?
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272011AIDS Vaccines And Preexposure Prophylaxis: Is Synergy Possible?
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282011Reasons For Ineligibility In Phase 1 And 2A HIV Vaccine Clinical Trials At Kenya Aids Vaccine Initiative (KAVI), Kenya
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292011Biological Factors That May Contribute To Regional And Racial Disparities In HIV Prevalence.
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302011Author's Reply: Most HIV Transmission In Sub-Saharan Africa Occurs Through Sex
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312011Prevention Of Human Immunodeficiency Virus Breastmilk Transmission With Copper Oxide: Proof-of-concept Study.
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322011Human Leukocyte Antigen Variants B*44 And B*57 Are Consistently Favorable During Two Distinct Phases Of Primary HIV-1 Infection In Sub-Saharan Africans With Several Viral Subtypes
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332011International Seroepidemiology Of Adenovirus Serotypes 5, 26, 35, And 48 In Pediatric And Adult Populations
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342011Characterization Of A Human Cervical CD4+ T Cell Subset Coexpressing Multiple Markers Of HIV Susceptibility
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352011Prevalence Of Specific Neutralizing Antibodies Against Sendai Virus In Populations From Different Geographic Areas: Implications For AIDS Vaccine Development Using Sendai Virus Vectors
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362010Viral Inhibition Assay: A CD8 T-cell Neutralization Assay For Use In Clinical Trials Of Human Immunodeficiency Virus-1 Vaccine Candidates
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372010Safety And Immunogenicity Study Of Multiclade HIV-1 Adenoviral Vector Vaccine Alone Or As Boost Following A Multiclade HIV-1 DNA Vaccine In Africa
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382010Transmitted HIV Type 1 Drug Resistance Among Individuals With Recent HIV Infection In East And Southern Africa
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392010Molecular Characterization Of HIV Type 1 Among HIV-Infected Respondents In A Cohort Being Prepared For HIV Phase III Vaccine Clinical Trials, Western Kenya.
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402010Affordable In-house Antiretroviral Drug Resistance Assay With Good Performance In Non-subtype B HIV-1
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412010Sensitivity And Specificity Of HIV Rapid Tests Used For Research And Voluntary Counselling And Testing
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422009Issues Around HIV-1 Diagnosis
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432009Pregnancy Rates Among Female Participants In Phase I And Phase IIA AIDS Vaccine Clinical Trials In Kenya.
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442009Serologic Testing Algorithm For Recent HIV Seroconversion In Estimating Incidence Of HIV-1 Among Adults Visiting A VCT Centre At A Kenyan Tertiary Health Institution
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452009Concordant Proficiency In Measurement Of T-cell Immunity In Human Immunodeficiency Virus Vaccine Clinical Trials By Peripheral Blood Mononuclear Cell And Enzyme-linked Immunospot Assays In Laboratories From Three Continents.
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462009CLSI-derived Hematology And Biochemistry Reference Intervals For Healthy Adults In Eastern And Southern Africa
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472009A Survey Of Legionella Pneumophila Among Pneumonia Patients At Kenyatta National Hospital
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482008Stevens W, Kamali A, Karita E, Anzala O, Sanders EJ, Jaoko W, Kaleebu P, Mulenga J, Dally L, Fast P, Gilmour J, Farah B, Birungi J, Hughes P, Manigart O, Stevens G, Yates S, Thomson H, Von Lieven A, Krebs M, Price MA, Stoll-Johnson L, Ketter N.aseline Mor
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492008Jaoko W, Nakwagala FN, Anzala O, Manyonyi GO, Birungi J, Nanvubya A, Bashir F, Bhatt K, Ogutu H, Wakasiaka S, Matu L, Waruingi W, Odada J, Oyaro M, Indangasi J, Ndinya-Achola J, Konde C, Mugisha E, Fast P, Schmidt C, Gilmour J, Tarragona T, Smith C, Barin
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502008Stevens W, Kamali A, Karita E, Anzala O, Sanders EJ, Jaoko W, Kaleebu P, Mulenga J, Dally L, Fast P, Gilmour J, Farah B, Birungi J, Hughes P, Manigart O, Stevens G, Yates S, Thomson H, Von Lieven A, Krebs M, Price MA, Stoll-Johnson L, Ketter N.Baseline Mo
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512007Gitura B, Joshi MD, Lule GN, Anzala O.Total Lymphocyte Count As A Surrogate Marker For CD4+ T Cell Count In Initiating Antiretroviral Therapy At Kenyatta National Hospital, Nairobi.East Afr Med J. 2007 Oct;84(10):466-72.
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522007Karita E, Price M, Hunter E, Chomba E, Allen S, Fei L, Kamali A, Sanders EJ, Anzala O, Katende M, Ketter N; The IAVI Collaborative Seroprevalence And Incidence Study Team.Investigating The Utility Of The HIV-1 BED Capture Enzyme Immunoassay Using Cross-se
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532007McKinnon LR, Ball TB, Wachihi C, McLaren PJ, Waruk JL, Mao X, Ramdahin S, Anzala AO, Kamene J, Luo M, Fowke KR, Plummer FA.Epitope Cross-reactivity Frequently Differs Between Central And Effector Memory HIV-specific CD8+ T Cells. J Immunol. 2007 Mar 15;17
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542006Koesters SA, Alimonti JB, Wachihi C, Matu L, ANZALA OA, Kimani J, Embree JE, Plummer FA, Fowke KR. IL-7Ralpha Expression On DC4+ T Lymphocytes Decreases With HIV Disease Progression And Inversely Correlates With Immune Activation. Eur J Immunol. 2006 Feb;
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552006Khurana S, Needham J, Park S, Mathieson B, Busch MP, Nemo G, Nyambi P, Zolla-Pazner S, Laal S, Mulenga J, Chomba E, Hunter E, Allen S, McIntyre J, Hewlett I, Lee S, Tang S, Cowan E, Beyrer C, Altfeld M, Yu XG, Tounkara A, Koita O, Kamali A, Nguyen N, Grah
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562006Koesters SA, Alimonti JB, Wachihi C, Matu L, Anzala O, Kimani J, Embree JE, Plummer FA, Fowke KR.IL-7Ralpha Expression On CD4+ T Lymphocytes Decreases With HIV Disease Progression And Inversely Correlates With Immune Activation.Eur J Immunol. 2006 Feb;36(
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572006Koesters SA, Alimonti JB, Wachihi C, Matu L, Anzala O, Kimani J, Embree JE, Plummer FA, Fowke KR.IL-7Ralpha Expression On CD4+ T Lymphocytes Decreases With HIV Disease Progression And Inversely Correlates With Immune Activation. Eur J Immunol. 2006 Feb;36
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582006Anzala F, Mor
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592006Standardization Of Cytokine Flow Cytometry Assays
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602005Schroeder TL, Burger H, Weiser B, Bengualid V, Kimani J, ANZALA AO, Parker MM, Lamson D, Philpott SM. Characterization Of Intersubtype Recombinant HIV Type 1 Genomes Using A Nonradioactive Heteroduplex Tracking Assay. AIDS Res Hum Retroviruses, 2005 April
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612005Maecker HT, Rinfret A, D'Souza P, Darden J, Roig E, Landry C, Hayes P, Birungi J, ANZALA O, Garcia M, Harari A, Frank I, Baydo R, Baker M, Holbrook J, Ottinger J, Lamoreaux L, Epling CL, Sinclair E, Suni MA, Punt K, Calarota S, El-Bahi S, Alter G, Maila H
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622005Karuru JW, Lule GN, Joshi M, Anzala O.Prevalence Of HCV And HCV/HIV Co-infection Among In-patients At The Kenyatta National Hospital. East Afr Med J. 2005 Apr;82(4):170-2.
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632005Karuru JW, Lule GN, Joshi M, Anzala O.Prevalence Of HCV And HIV/HCV Co-infection Among Volunteer Blood Donors And VCT Clients.East Afr Med J. 2005 Apr;82(4):166-9.
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642004Construction Of An Infectious HIV Type 1 Molecular Clone From An African Patient With A Subtype D/C Recombinant Virus. Shi B, Philpott SM, Weiser B, Kuiken C, Brunner C, Fang G, Fowke KR, Plummer FA, Rowland-Jones S, Bwayo JJ, Anzala AO, Kimani J, Kaul R,
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652004Long-term Survivors In Nairobi: Complete HIV-1 RNA Sequences And Immunogenetic Associations. Fang G, Kuiken C, Weiser B, Rowland-Jones S, Plummer F, Chen CH, Kaul R, Anzala AO, Bwayo JJ, Kimani J, Philpott SM, Kitchen C, Sinsheimer JS, Gaschen B, Lang D,
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662004Recombination Following Superinfection By HIV-1. Fang G, Weiser B, Kuiken C, Philpott SM, Rowland-Jones S, Plummer F, Kimani J, Shi B, Kaul R, Bwayo JJ, Anzala O, Burger H. AIDS. 2004 Jan 23;18(2):153-9.
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672004Fang G, Weiser B, Kuken C, Philpott SM, Rowland-Jones S, Plummer F, Kimani J, Shi B, Kaul R, Bwayo J, ANZALA O, Burger H. Recombination Following Superinfection By HIV-1. AIDS.2004 Jan 23;18(2):153-9.
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682004Fangg, Kuiken C, Weiser B, Rowland-Jones S, Plummer F, Chen CH, Kaul R, ANZALA AO, Bwayo JJ, Kimani J, Philpott SM, Kitchen C, Sinsheimer JS, Gaschen B, Lang D, Shi B, Kemal KS, Rostron T, Brunner C, Beddows S, Sattenau Q, Paxinos E, Oyugi J, Burger H. Lo
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692004Shi B, Philpott SM, Weiser B, Kuiken , Brunner C, Fang G, Fowke KR, Plummer FA, Rowland-Jones S, Bwayo J, ANZALA AO, Kimani J, Kaul R, Burger H. Construction Of An Infectious HIV Type 1 Molecular Clone From An African Patient With A Subtype D/C Recombinan
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702004Koesters SA, Matu L, Kiama P, ANZALA O, Embree J, Plummer FA, Kimani J, Fowke KR. Elevation Of Immune Activation In Kenyan Women Is Associated With Alterations In Immune Function: Implications For Vaccine Development. J Clin Immunol. 2004 Nov;24(6):702-9.
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712003Resistance Following Chronic HIV-1 Exposure Is Associated With Increased Virus-driven IFN Gamma And Reduced IL-4 Synthesis, Independent Of Changes In Other Th2-associated Cytokines
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722002Rapid Development Of Symptomatic Hiv-1 Related Disease In East-african Prostitutes
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732001Trivedi HN, Plummer FA, ANZALA AO, Njagi E, Bwayo JJ, Ngugi EN, Embree JE, Hayglass KT. Resistance To HIV-1 Infection Among African Sex Workers Is Associated With Global Hypo Responsiveness In Interleukin 4 Production. FASEB J. 2001 Aug; 15(10):1795-7.
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742000Acute Sexually Transmitted Infections Increase Human Immunodeficiency Virus Type 1 Plasma Viremia, Increase Plasma Type 2 Cytokines, And Decrease CD4 Cell Counts. Anzala AO, Simonsen JN, Kimani J, Ball TB, Nagelkerke NJ, Rutherford J, Ngugi EN, Bwayo JJ,
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752000ANZALA AO, Simonsen JN, Kimani J, Ball TB, Ngugi EN, Bwayo JJ, Nagelkerke N, Kakai NJD, Plummer FA. Role Of Sexually Transmitted Infections In Accelerated HIV-1 Disease Progression. J. Infect Dis. 2000; 182:459-66.
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762000Murray MC, Embree JE, Ramdahin SG, Anzala AO, Njenga S, Plummer FA Effect Of Human Immunodeficiency Virus (HIV) Type 1 Viral Genotype On Mother-to-Child Transmission Of HIV-1. J Infect Dis. 2000 181:746-9.
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772000Melanie C.M., Joanne Embree, Sue G. Ramdahin, ANZALA AO, Simon Njenga, Et Al. Effect Of Human Immunodeficiency Virus (HIV) Type 1 Viral Genotype On Mother-to-Child Transmission Of HIV-1. J Infect Dis. 2000 181:746-9.
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782000Murray MC, Embree JE, Ramdahin SG, ANZALA AO, Njenga S, Plummer FA. Effect Of Human Immunodeficiency Virus (HIV) Type 1 Viral Genotype On Mother-to-child Transmission Of HIV-1. J Infect Dis.2000 Feb;181(2):746-9.
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792000ANZALA AO, Simonsen JN, Kimani J, Ball TB, Nagelkerke NJ, Rutherford J, Ngugi EN, Bwayo JJ, Plummer FA. Acute Sexually Transmitted Infections Increase Human Inmmunodeficiency Virus Type 1 Plasma Viremia, Increase Plasma Type 2 Cytokines, And Decrease CD4
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801999Kenneth E. Robbins, Leondios G Kostrikis, Teresa M. Brown, ANZALA AO, Sunny Shin, Francis A Plummer, Marcia L Kalish. Genetic Analysis Of Human Immunodeficiency Virus Type 1 Strains In Kenya: A Comparison Using Phylogenetic Analysis And Combinational Melt
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811999Robbins KE, Kostrikis LG, Brown TM, ANZALA O, Shin S, Plummer FA, Kalish ML. Genetic Analysis Of Human Immunodeficiency Virus Type 1 Strains In Kenya: A Comparison Using Phylogenetic Analysis And A Combinatorial Melting Assay. AIDS Res Hum Retroviruses. 1
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821998Luscher MA, Choy G, Njagi E, Bwayo JJ, Anzala AO, Ndinya-Achola JO, Ball TB, Wade JA, Plummer FA, Barber BH, MacDonald KS.Naturally Occurring IgG Anti-HLA Alloantibody Does Not Correlate With HIV Type 1 Resistance In Nairobi Prostitutes.AIDS Res Hum Retro
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831998ANZALA AO, Ball B, Rostron T, Smith M, O
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841998Mark A Luscher, Greory Choy, Ephanta Njagi, Bwayo JJ, ANZALA AO, Ndinya-Achola J, Kelly MacDonald Et Al. Naturally Occuring IgG Anti-HLA Alloantibody Does Not Correlate With HIV Type 1 Resistance In Nairobi Prostitutes. AIDS Res Hum Retroviruses. 1998 Jan
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851998The 64I Allele Of The CCR2 Chemokine Receptor Is Strongly Associated With Delayed Disease Progression In A Cohort Of African Prostitutes
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861998CCR2-64I Allele And Genotype Association With Delayed AIDS Progression In African Women. University Of Nairobi Collaboration For HIV Research
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871997Resistance To HIV-1 Infection Among Persistently Seronegative Prostitutes In Nairobi, Kenya [see Comments]. Fowke KR; Nagelkerke NJ; Kimani J; Simonsen JN; Anzala AO; Bwayo JJ; MacDonald KS; Ngugi EN; Plummer FA. Comment In: Lancet 1997 Mar 1;349 (9052):6
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881996Rapid Progression To Disease In African Sex Workers With Human Immunodeficiency Virus Type 1 Infection [see Comments] [published Erratum Appears In J InfectDis1996 Jun; 173(6):1529] Anzala OA; Nagelkerke NJ; Bwayo J.; Holton D Moses S; Ngugi EN; Ndinya-Ac
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891996Fowke KR, Nagelkerke NJD, Kimani J, Simosen JN, ANZALA AO, Bwayo JJ, MacDonald KS, Ngugi EN, Plummer FA, Resistance To HIV-1 Infection Among Persistently Seronegative Prostitutes In Nairobi, Kenya. Lancet 1996; 348: 1347-51.
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901995Rapid Progression To Disease In African Sex Workers With Human Immunodificiency Virus Type 1 Infection. Anzala AO, Nagelkerke NJD, Bwayo J.J, Holton D, Moses S, Ngugi EN, Ndinya-Achola JO And Plummer FA. Journal Of Infectious Diseases 1995; 171: 686-9.
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911995Comparison Of The Decline In CD4 Counts In HIV -1 Seropositive Female Sex Workers And Women From The General Population In Nairobi, Kenya. Journal Of Acquired Immune Deficiency Syndrome. Bwayo J.J, Nagelkerke NJD, Moses S, Embree J, Ngugi EN, Mwatha A, Ki
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921995Breast Feeding And Immunity To Intestinal Infections.Kakai R,Bwayo J.J,Wamola I.A, Ndinya- Achola,Nagelkerke NJD,Anzala AO,Plummer FA.East African Medical Journal 1995;72:1.
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931995Low Dose Erythromycin Regimen For The Treatment Of Chancroid. Kimani J; Bwayo JJ; Anzala AO; MacLean I; Mwatha A; Choudri SH; Plummer FA; Ronald AR. East Afr Med J. 1995 Oct;72(10):645-8.
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941995Anzala AO, Nagelkerke JD, Bwayo JJ, Holton D, Moses S, Ngugi EN, Ndinya-Achola JO, Plummer FA. Rapid Progression To Disease In African Sex Workers With Human Immunodeficiency Virus Type 1 Infection. J. Infect. Dis. 171: 686 - 689, 1995
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951995Bwayo JJ, Nagelkerke NJD, Moses S, Embree J, Ngugi EN, Mwatha A, Kimani J, ANZALA AO, Choundhri S, Ndinya-Achola JO, Plummer FA. Comparison Of The Declines In CD4 Counts In HIV-1-seropositive Female Sex Workers And Women From The General Population In Nai
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961995Kimani J, Bwayo JJ, ANZALA AO, Maclean I, Mwatha A, Choudhri SH, Plummer FA, Ronald AR. Low Dose Erythromycin Regimen For The Treatement Of Chancroid. East African Med. J. 1995: 72(10):645-8.
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971995Kakai R, Bwayo JJ, Wamola IA, Ndinya-Achola JO, ANZALA AO, Plummer FA Et Al. Breastfeeding And Immunity To Intestinal Infections. East Africa Med. J. 1995 Mar; 72(3): 150-4
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981992Kreiss JK, Ngugi E, Holmes K, Ndinya-Achola J, Waiyaki P, Roberts PL, Ruminjo I, Sajabi R, Kimata J, Flemming TR, ANZALA AO, Holton D, Plummer F. Efficacy Of Nonoxnol-9 Contraceptive Sponge Use In Preventing Heterosexual Acquisition Of HIV In Nairobi Pros
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991991Moses S, Plummer FA, Ngugi EN, Nagelkerke NJD, Anzala AO, Ndinya-Achola JO.Controlling HIV In Africa: Effectiveness And Cost Of Intervention In A High Frequency STD Transmitter Core Group. AIDS 5: 407 - 411, 1991
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1001990Transition Dynamics Of HIV Disease In A Cohort Of African Prostitutes: A Markov Model Approach
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