The Second HIV Mucosal Systems Meeting
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Location / Venue: 

Chicago, Illinois

The Second HIV Mucosal Systems Meeting chaired by Prof. Thomas Hope, was held May 6th - 8th, 2019, at Prentice Woman's Hospital, in Chicago, Illinois (image 1). Ms. Matrona Akiso Mbendo and Dr. Marianne Mureithi from KAVI-ICR, University of Nairobi attended the meeting. The goal of the meeting was to information and interactions on research relating to HIV interactions with mucosal systems in general. Speakers included; Kristina Broliden, Douglas Lauffenburger, Christiane Moog,  Don Sodora, Charles Wira,  Cara Wilson,  Deborah Anderson, Francois Villinger,  Kyle McKinnon, Rupert Kaul and young investigators such as Ann Carias and Vineet Joag among others.

Dr. Marianne Mureithi  co-chaired the first session on ‘’Advances in mucosal systems.’ Which saw Prof. Broliden discuss In situ image analysis and protein profiling of the genital mucosa reveal epithelial barrier. Other speakers of this session discussed other advances in mucosal systems research such as Cross‐Species Translation of Biological Information via Statistical and Machine Learning Computational Frameworks by Douglas Lauffenburger. Adam Carrico highlighted a Bio‐behavioral correlates of rectal inflammation in HIV‐negative sexual minority men.  Doris Wilfingseder illustrated a complementary view on HIV transmission and Thomas Cherpes from Stanford University discussed Hormonal contraception and HIV transmission using animal models. The first session was concluded by Dr. Ann Carias an early investigator who won an award of the best presenters. Dr. Carias highlighted her research on variety of methodologies for antibody delivery to anatomical sites such as whole organs and various mucosal sites and began to unravel the complexities of how antibodies are delivered to sites involved in HIV transmission and pathogenesis.

The second session was co-chaired by Timothy Ray Brown also known as the Berlin Patient; the first man to be cured of HIV/AIDS in the world. This session had various speakers including one of our collaborator’s; Rupert Kaul. All the speakers focused on the role of the mucosa in HIV pathogenesis and cure. The third session main theme was HIV transmission and the mucosa and the various speakers highlighted how different aspects of the reproductive system affect HIV transmission such as menopause, microbiome, and other sexually transmitted pathogens such as Chlamydia trachomatis. This session speakers included Lyle Mckinnon and Vineet Jaog all affiliated with KAVI-ICR. An interesting discussion on techniques used to Characterize Migratory and Tissue‐Resident HIV Target CD4+ T Cells in the Foreskin Epidermis was one of the highlights of this session.

Session 4 soon followed which focused in more details the role of the Microbiome on mucosal immunity and its interactions with HIV. Various speakers such as Jason Brenchley elegantly highlighted microbiome dysbiosis and inflammation and Cara Wilson introduced HIV and Geriome topic. The final session titled Novel interventions & models targeting mucosal tissues had interesting topics such Monoclonal Antibody-based Multipurpose Prevention Technology done by Deborah Anderson. Here, she highlighted her work on human monoclonal antibody (mAb)-releasing vaginal films and rings as a multipurpose prevention technology (MPT) platform to provide women protection against sexually transmitted infections (STIs) and unintended pregnancy. Other topics in this session included the neovaginal microbiome of transgender women post‐ gender reassignment surgery which was described as different compared to the normal woman.

Later Prof. Tom Hope hosted a small satellite session Circumcision. In this session the South African group led by Clive Gray focused on their very interesting work and data on foreskin immunology and the impact of HIV and other STIs. Jessica Prodger and Rupert Kaul also highlighted their research on foreskins from the Rakai site in Uganda.

Later the KAVI-ICR team spent some time in the Hope’s laboratory at the Feinberg School of Medicine and went through various aspects of the ongoing KAVI-ICR-Hope Laboratory collaboration.

Expiry Date: 
Wed, 2021-06-30 (All day)