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Dr. Day’s research program is based on characterization of cellular immune responses in pediatric and adult cohorts across a spectrum of TB and HIV infection states. Specific research areas include 1) characterization of frequency, phenotype, and function of antigen-specific T cells and relationship to antigen load and disease status; 2) analysis of mechanisms of immune regulation of antigen-specific T cell responses; 3) analysis of NK cell correlates of protection in M. tuberculosis infection; and 4) evaluation of the effect of maternal HIV exposure on the phenotype, transcriptome and epigenome of innate and adaptive immunity to M. tuberculosis in HIV-exposed uninfected infants and children.